Antihormone treatment differentially regulates PSA secretion, PSMA expression and 68Ga-PSMA uptake in LNCaP cells.

C S MathyT MayrS KürpigM MeisenheimerR C Dolscheid-PommerichB Stoffel-WagnerG KristiansenM EsslerM H MudersRalph A Bundschuh

Published in: Journal of cancer research and clinical oncology (2021)

Our data indicate that PSA secretion and PSMA expression are differentially regulated upon anti-androgen treatment. This finding might be important for the interpretation of 68Ga-PSMA PET images in monitoring therapies with abiraterone and VPC-13566 in prostate cancer patients, but needs to be validated in vivo.

Keyphrases

pet ct
prostate cancer
pet imaging
poor prognosis
positron emission tomography
induced apoptosis
transcription factor
computed tomography
radical prostatectomy
binding protein
machine learning
optical coherence tomography
big data
artificial intelligence
oxidative stress