Novel insights into paclitaxel's role on tumor-associated macrophages in enhancing PD-1 blockade in breast cancer treatment.
Yoonjeong ChoiSeong A KimHanul JungEunhae KimYoon Kyoung KimSeohyun KimJaehyun KimYeji LeeMin Kyoung JoJiwan WooYakdol ChoDongjoo LeeHongyoon ChoiCherlhyun JeongGi-Hoon NamMinsu KwonIn-San KimPublished in: Journal for immunotherapy of cancer (2024)
This study reveals how PTX boosts the effectiveness of PD-1 inhibitors in treating TNBC. We found that PTX activates TLR4 signaling in TAMs. This activation enhances their ability to present antigens, thereby boosting CD8+ T cell antitumor responses. These findings not only shed light on PTX's immunomodulatory role in TNBC but also underscore the potential of targeting TAMs' antigen presentation capabilities in immunotherapy approaches.