Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation.
Divya SekarChristina DillmannEvelyn Sirait-FischerAnnika F FinkAleksandra ZivkovicNatalie BaumElisabeth StrackStephan KlattSven ZukunftStefan WallnerArnaud DescotCatherine OleschPriscila da SilvaAndreas von KnethenTobias SchmidSabine GröschSoni Savai PullamsettiNerea FerreirósIngrid FlemingSourav GhoshCarla V RothlinHolger StarkHind MedyoufBernhard BrüneAndreas WeigertPublished in: Cancer research (2022)
This study shows that inhibiting the production of ether-phosphatidylserine by targeting phosphatidylserine synthase PTDSS1 limits tumor-associated macrophage expansion and breast tumor growth.