A deficiency of Dec2 triggers periodontal inflammation and pyroptosis.

Shunichi OkaXiaoyan LiFuyuki SatoFengzhu ZhangNitesh TewariIl-Shin KimLiangjun ZhongNobushiro HamadaMakoto MakishimaYi Liu Ujjal Kumar Bhawal

Published in: Journal of periodontal research (2021)

Our results demonstrate that Dec2 alleviates periodontal pyroptosis by regulating the expression of NF-κB, caspase-1 and GSDMD, suggesting that Dec2 is a crucial component of inflammasome activation and subsequent pyroptosis.

Keyphrases

nlrp inflammasome
oxidative stress
poor prognosis
signaling pathway
cell death
lps induced
induced apoptosis
binding protein
inflammatory response
replacement therapy
toll like receptor
endoplasmic reticulum stress