A randomized translational study on protein- and glucose metabolism in skeletal muscles evaluated by gene-ontology, following preoperative oral carbohydrate loading compared to overnight peripheral parenteral nutrition (PPN) before major cancer surgery.
Britt-Marie IresjöUlrika SmedhCecilia EngströmJan PerssonChristian MårtenssonKent LundholmPublished in: Journal of translational medicine (2024)
Conventional overnight preoperative PPN seems effective to induce and support improved muscle protein metabolism in patients aimed at major cancer surgery while preoperative oral carbohydrate loading, according to ERAS-protocols, was ineffective to improve skeletal muscle catabolism and should therefore not be recommended before major cancer surgery. Trial registration Clinical trials.gov: NCT05080816, Registered June 10th 2021- Retrospectively registered. https://clinicaltrials.gov/study/NCT05080816.
Keyphrases
- papillary thyroid
- minimally invasive
- skeletal muscle
- clinical trial
- coronary artery bypass
- squamous cell
- patients undergoing
- end stage renal disease
- ejection fraction
- newly diagnosed
- squamous cell carcinoma
- lymph node metastasis
- randomized controlled trial
- gene expression
- type diabetes
- binding protein
- copy number
- childhood cancer
- prognostic factors
- genome wide
- young adults
- dna methylation
- genome wide analysis