Current Updates on the Understanding of the Role of DNA Methylation on Obesity.
Mohammad Parezal LastialnoMuhammad Hasan BashariEko Fuji AriyantoPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2024)
Obesity is a condition in which there is an accumulation of excess body fat leading to a weight far above the normal range that poses significant health risks. According to WHO, 8 billion people in the world were obese in 2022. Consequently, obesity has become a pandemic with negative impacts on both global health and economies. Obesity is influenced by various factors including environmental influences, lifestyle choices, gut microbiota, genetic factors, and epigenetic mechanisms such as DNA methylation. DNA methylation can affect an individual's phenotype and condition without altering their DNA sequence. It is the most extensively studied epigenetic alteration and it plays an important part in controlling gene activity associated with obesity. Numerous studies have indicated that DNA methylation is implicated in obesity, thus this review aims to elaborate the roles of DNA methylation to inform the development of preventive measures for obesity.
Keyphrases
- dna methylation
- weight loss
- metabolic syndrome
- insulin resistance
- genome wide
- type diabetes
- weight gain
- high fat diet induced
- gene expression
- bariatric surgery
- copy number
- global health
- adipose tissue
- cardiovascular disease
- physical activity
- sars cov
- coronavirus disease
- multidrug resistant
- obese patients
- circulating tumor
- transcription factor