ISG15 as a prognostic biomarker in solitary fibrous tumour.

Jose L Mondaza-HernandezDavid S MouraMaría Lopez-AlvarezPaloma Sanchez-BustosElena Blanco-AlcainaCarolina Castilla-RamirezPaola ColliniJose Merino-GarciaJorge ZamoraJaime Carrillo-GarciaRoberta MaestroNadia HindiJesus Garcia-FoncillasJavier Martín-Broto

Published in: Cellular and molecular life sciences : CMLS (2022)

ISG15 is a prognostic factor in malignant SFT, regulating the expression of CSC-related genes and CSCs maintenance. Our results suggest that ISG15 could be a novel therapeutic target in SFT, which could improve the efficacy of the currently available treatments.

Keyphrases

prognostic factors
poor prognosis
binding protein
cancer stem cells