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Highly pathogenic avian influenza (A/H5N1) virus outbreaks in Lesotho, May 2021.

Mabusetsa Joseph Raporoto MakaloWilliam G DundonTirumala Bharani Kumar SettypalliSneha DattaCharles Euloge LamienGiovanni CattoliMoeketsi S PhalatsiRelebohile J LepheanaMpaliseng MatlaliRelebohile G MahloaneMarosi MolomoPalesa C Mphaka
Published in: Emerging microbes & infections (2022)
In May 2021, Lesotho reported its first outbreak of highly pathogenic avian influenza (HPAI) to the OIE. Samples were collected from infected poultry and the virus was confirmed by molecular tests to be of the H5N1 subtype. Full genome sequencing and phylogenetic analysis revealed that the viruses belonged to clade 2.3.4.4b and showed high identity with A/H5N1 viruses identified in Nigeria and Senegal in early 2021. The identification of A/H5N1 HPAI in Lesotho has important implications for disease management and food security in the region.
Keyphrases
  • single cell
  • global health
  • genetic diversity
  • antimicrobial resistance
  • gene expression
  • disease virus
  • single molecule
  • risk assessment
  • climate change