Perillyl alcohol for pediatric TP53- and RAS-mutated SHH-medulloblastoma: an in vitro and in vivo translational pre-clinical study.

Marcela de Oliveira SilvaGraziella Ribeiro de SousaSarah Capelupe SimõesPatrícia NicolucciEdwin TamashiroFabiano SaggioroRicardo Santos de OliveiraMaría Sol Brassesco

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2021)

POH presents robust in vitro antimedulloblastoma effects and sensitizes cell lines to other conventional therapeutics, reducing tumor volume when administered intraperitoneally. Nevertheless, further improvement of delivery devices and/or drug formulations are needed to better characterize its effectiveness through inhalation.

Keyphrases

wild type
randomized controlled trial
systematic review
small molecule
alcohol consumption
emergency department
double blind
young adults