Postoperative radiotherapy for patients with completely resected stage IIIA-N2 non-small cell lung cancer: opt-in or opt-out.
Lucheng ZhuBing XiaShenglin MaPublished in: Thoracic cancer (2022)
The role of adjuvant radiotherapy in completely resected pIIIA-N2 non-small cell lung cancer (NSCLC) has long been debated. Evidence from previous retrospective and prospective studies showed that postoperative radiotherapy could reduce the incidence of local recurrence and prolong disease-free survival, while two recently reported randomized controlled trials (lung ART and PORT-C) both demonstrated no survival benefit of postoperative radiotherapy. The great gap between our knowledge and reality has made us rethink the value of postoperative radiotherapy. In this mini review, we elaborate on the role of postoperative radiotherapy in completely resected pIIIA-N2 NSCLC.
Keyphrases
- early stage
- locally advanced
- free survival
- patients undergoing
- radiation therapy
- radiation induced
- small cell lung cancer
- randomized controlled trial
- lymph node
- healthcare
- rectal cancer
- systematic review
- risk factors
- clinical trial
- advanced non small cell lung cancer
- epidermal growth factor receptor
- antiretroviral therapy
- robot assisted