Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial.
Søren MarkerMette KragAnders PernerJørn WetterslevTheis LangeMatt P WiseMark BorthwickStepani BendelFrederik KeusAnne Berit GuttormsenJoerg C SchefoldBodil S RasmussenThomas ElkmannMorten BestleBjørn ArenkielJon Henrik LaakeMaj K KamperMaarit LångMalgorzata B Pawlowicz-DworzanskaSari KarlssonJanne Henrik LiisananttiNilanjan DeyHeidi KnudsenAnders GranholmMorten Hylander Möllernull nullPublished in: Acta anaesthesiologica Scandinavica (2019)
We did not observe a difference in 1-year mortality among acutely admitted adult ICU patients with risk factors for gastrointestinal bleeding allocated to stress ulcer prophylaxis with pantoprazole or placebo during the ICU stay. (The SUP-ICU trial was funded by Innovation Fund Denmark and others; ClinicalTrials.gov number, NCT02467621).
Keyphrases
- intensive care unit
- mechanical ventilation
- phase iii
- end stage renal disease
- clinical trial
- study protocol
- cardiovascular events
- newly diagnosed
- chronic kidney disease
- randomized controlled trial
- risk factors
- acute respiratory distress syndrome
- coronary artery disease
- health insurance
- open label
- cardiovascular disease
- patient reported outcomes
- double blind