Total Synthesis of Meayamycin and O-Acyl Analogues.
Christopher GartshoreShinji TadanoPrem B ChandaAnindya SarkarNaidu S ChowdariSanjeev GangwarQian ZhangGregory D ViteJelena MomirovDale L BogerPublished in: Organic letters (2020)
A short, scalable total synthesis of meayamycin is described by an approach that entails a longest linear sequence of 12 steps (22 steps overall) from commercially available chiral pool materials (ethyl l-lactate, BocNH-Thr-OH, and d-ribose) and introduces the most straightforward preparation of the right-hand subunit detailed to date. The use of the approach in the divergent synthesis of a representative series of O-acyl analogues is exemplified.