Variation in the expression level of MALAT1, MIAT and XIST lncRNAs in coronary artery disease patients with and without type 2 diabetes mellitus.
Nasim SohrabifarSayyed Mohammad Hossein GhaderianSaeed Alipour ParsaHamid GhaediHossein JafariPublished in: Archives of physiology and biochemistry (2020)
Background: The MALAT1, MIAT, and XIST long noncoding RNAs (lncRNAs) participate in the pathogenesis of complex diseases and also serve as diagnostic markers. The study aimed to assess their expressions in CAD patients with or without T2DM against diabetic and non-diabetic controls.Methods: The expression levels of three lncRNAs in 50 CAD patients (with or without diabetes) and 50 non-CAD subjects (with or without diabetes) were evaluated by using the TaqMan Assay method.Results: MALAT1 and MIAT were upregulated in CAD patients (p Value= .0008 and .0078, respectively). The expression level of XIST was significantly elevated diabetic compared to non-diabetic CAD patients (p Value= .0003). MALAT1 gene had the highest diagnostic power for discrimination of CAD patients from controls (AUC= 0.682, p Value=.001).Conclusions: The current study supports the participation of lncRNAs in the pathogenesis of CAD and T2DM and highlights their potential as diagnostic biomarkers.
Keyphrases
- coronary artery disease
- end stage renal disease
- type diabetes
- ejection fraction
- chronic kidney disease
- newly diagnosed
- poor prognosis
- percutaneous coronary intervention
- cardiovascular disease
- peritoneal dialysis
- coronary artery bypass grafting
- heart failure
- glycemic control
- metabolic syndrome
- adipose tissue
- patient reported outcomes
- genome wide
- long non coding rna
- single cell
- copy number
- weight loss
- risk assessment
- left ventricular