Assessment of global histone acetylation in pediatric and adolescent obesity: Correlations with SIRT1 expression and metabolic-inflammatory profiles.
Nima TaghizadehSoha MohammadiZeynab YousefiPegah GolpourAlemeh TaheriMohammad Hasan MalekiMitra NourbakhshMona NourbakhshMaryam Razzaghy AzarPublished in: PloS one (2023)
Histone acetylation was enhanced in children and adolescents with obesity, potentially resulting from down-regulation of SIRT1, and could play a role in the obesity-associated metabolic abnormalities and insulin resistance. Targeting global histone acetylation modulation might be considered as an epigenetic approach for early obesity management.
Keyphrases
- insulin resistance
- metabolic syndrome
- high fat diet induced
- weight loss
- type diabetes
- dna methylation
- adipose tissue
- weight gain
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- oxidative stress
- young adults
- poor prognosis
- histone deacetylase
- physical activity
- glycemic control
- drug delivery
- long non coding rna