Central-line associated bloodstream infections in intensive care units before and after implementation of daily antiseptic bathing with chlorhexidine or octenidine: a post-hoc analysis of a cluster-randomised controlled trial.

Luisa A DenkelFrank SchwabJörg ClausmeyerMichael BehnkeJennifer GolembusSolvy WolkePetra GastmeierChristine Geffersnull null

Published in: Antimicrobial resistance and infection control (2023)

In this post-hoc analysis of a cRCT, the application of 2% chlorhexidine-impregnated cloths reduced ICU-attributable CLABSI. This preventive effect of chlorhexidine was restricted to CLABSI caused by gram-positive pathogens (CoNS). In contrast, 0.08% octenidine wash mitts did not reduce CLABSI rates in ICUs. Trial registration Registration number DRKS00010475, registration date August 18, 2016.

Keyphrases

intensive care unit
study protocol
gram negative
surgical site infection
mechanical ventilation
primary care
clinical trial
healthcare
magnetic resonance
randomized controlled trial
physical activity
phase iii
magnetic resonance imaging
computed tomography
acute respiratory distress syndrome