Mouse background genetics in biomedical research: The devil's in the details.

Ariel M HayHeather L HowieJames D GorhamAngelo D'AlessandroSteven L SpitalnikKrystalyn E Hudson James C Zimring

Published in: Transfusion (2021)

Thousands of articles published each year use gene-modified mice, yet genetic background issues are rarely considered. Assessment of such issues are not, but should become, routine norms of murine experimentation.

Keyphrases

genome wide
copy number
high fat diet induced
clinical practice
dna methylation
randomized controlled trial
genome wide identification
systematic review
type diabetes
meta analyses
insulin resistance
skeletal muscle
wild type