Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Naphannop SereesongsaengSara H McDowellJames F BurrowsChristopher J ScottRoberta E BurdenPublished in: Breast cancer research : BCR (2020)
In this study, we have identified that cysteine protease cathepsin V can suppress GATA3 expression in ER-positive breast cancers by facilitating its turnover via the proteasome. Therefore, targeting cathepsin V may represent a potential therapeutic strategy in ER-positive breast cancers, by restoring GATA3 protein expression, which is associated with a more favourable clinical outcome.