Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule.

Peng WuXiao-Tong SuZhong-Xiuzi GaoDan-Dan ZhangXin-Peng DuanYu XiaoOlivier StaubWen-Hui WangDao-Hong Lin

Published in: Journal of the American Society of Nephrology : JASN (2020)

Nedd4-2 regulates Kir4.1/Kir5.1 expression/activity in the DCT and modulates NCC expression by Kir4.1-dependent and Kir4.1-independent mechanisms. Basolateral Kir4.1/Kir5.1 activity in the DCT partially accounts for the stimulation of NCC activity/expression induced by deletion of Nedd4-2.

Keyphrases

poor prognosis
binding protein
minimally invasive