Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype.
Shirley N TangConnor GanttAna Salazar PuertaLucy BodineSafdar KhanNatalia Higuita-CastroDevina PurmessurPublished in: JOR spine (2023)
to drive reprogramming in mild to moderately degenerate AF cells from autopsy and severely degenerate AF cells from surgical patients toward a healthy phenotype and may be a potential nonviral gene therapy for LBP.