Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial.
Elvin KedhiBalazs BertaTomasz RolederRenicus S HermanidesEnrico FabrisAlexander J J IJsselmuidenFloris KauerFernando AlfonsoClemens von BirgelenJavier EscanedCyril CamaroMark W KennedyBruno PereiraMichael MagroHolger NefSebastian ReithArif Al NooryaniFernando Rivero-CrespoKrzysztof Piotr MalinowskiGiuseppe De LucaHector Garcia GarciaJuan F GranadaWojciech WojakowskiPublished in: European heart journal (2021)
Among DM patients with ≥1 FFR-negative lesions, TCFA-positive patients represented 25% of this population and were associated with a five-fold higher rate of MACE despite the absence of ischaemia. This discrepancy between the impact of vulnerable plaque and ischaemia on future adverse events may represent a paradigm shift for coronary artery disease risk stratification in DM patients.
Keyphrases
- coronary artery disease
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- type diabetes
- randomized controlled trial
- clinical trial
- metabolic syndrome
- heart failure
- adipose tissue
- insulin resistance
- percutaneous coronary intervention
- optical coherence tomography
- patient reported outcomes
- acute coronary syndrome
- cardiovascular events
- phase iii