Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development.
Lior GoldbergEric R HaasRyan UrakVibhuti VyasKhyatiben V PathakKrystine Garcia-MansfieldPatrick PirrotteJyotsana SinghalJames L FigarolaIbrahim AldossStephen J FormanXiuli WangPublished in: Cancer research (2024)
The spatiotemporal immunometabolic landscape of CD19-targeted CAR T cells from patients reveals metabolic adaptations in specific microenvironments that can be exploited to maximize the therapeutic efficacy of CAR T cells.