Patrick Pirrotte

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 30

Top Topics

Chronic Myeloid Leukemia

Dna Damage Response

Extracellular Matrix

Top Venues

Science advances

Nature communications

Neuro-oncology advances

This page only lists publications with an associated author ORCID identifier.

Publications

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer 5 (4) (2024)
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer 5 (4) (2024)
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer (2024)
Brett Taylor, Nanyun Tang, Yue Hao, Matthew Lee, Sen Peng, Rita Bybee, Lauren Hartman, Krystine Garcia-Mansfield, Ritin Sharma, Patrick Pirrotte, Jianhui Ma, Alison D Parisian, Frank B Furnari, Harshil D Dhruv, Michael E Berens
Glioblastoma vulnerability to neddylation inhibition is dependent on PTEN status, and dysregulation of the cell cycle and DNA replication. Neuro-oncology advances 6 (1) (2024)
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer 5 (4) (2024)
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer 5 (4) (2024)
Brett Taylor, Nanyun Tang, Yue Hao, Matthew Lee, Sen Peng, Rita Bybee, Lauren Hartman, Krystine Garcia-Mansfield, Ritin Sharma, Patrick Pirrotte, Jianhui Ma, Alison D Parisian, Frank B Furnari, Harshil D Dhruv, Michael E Berens
Glioblastoma vulnerability to neddylation inhibition is dependent on PTEN status, and dysregulation of the cell cycle and DNA replication. Neuro-oncology advances 6 (1) (2024)
Brett Taylor, Nanyun Tang, Yue Hao, Matthew Lee, Sen Peng, Rita Bybee, Lauren Hartman, Krystine Garcia-Mansfield, Ritin Sharma, Patrick Pirrotte, Jianhui Ma, Alison D Parisian, Frank B Furnari, Harshil D Dhruv, Michael E Berens
Glioblastoma vulnerability to neddylation inhibition is dependent on PTEN status, and dysregulation of the cell cycle and DNA replication. Neuro-oncology advances 6 (1) (2024)
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer 5 (4) (2024)
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer 5 (4) (2024)
Lior Goldberg, Eric R Haas, Ryan Urak, Vibhuti Vyas, Khyatiben V Pathak, Krystine Garcia-Mansfield, Patrick Pirrotte, Jyotsana Singhal, James L Figarola, Ibrahim Aldoss, Stephen J Forman, Xiuli Wang
Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development. Cancer research 84 (7) (2024)
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Y Ghoda, Jonathan S Serody, Benjamin G Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature cancer (2024)
Lior Goldberg, Eric R Haas, Ryan Urak, Vibhuti Vyas, Khyatiben V Pathak, Krystine Garcia-Mansfield, Patrick Pirrotte, Jyotsana Singhal, James L Figarola, Ibrahim Aldoss, Stephen J Forman, Xiuli Wang
Immunometabolic adaptation of CD19-targeted CAR T cells in the central nervous system microenvironment of patients promotes memory development. Cancer research (2024)
Vinay Singh Tanwar, Marpadga A Reddy, Sadhan Das, Vishnu Amaram Samara, Maryam Abdollahi, Suchismita Dey, Anil Bhanudas Gaikwad, Rituparna Ganguly, Kenneth Stapleton, Linda Lanting, Patrick Pirrotte, Rama Natarajan
Palmitic Acid-Induced Long Noncoding RNA PARAIL Regulates Inflammation via Interaction With RNA-Binding Protein ELAVL1 (ELAV Like RNA-Binding Protein 1) in Monocytes and Macrophages. Arteriosclerosis, thrombosis, and vascular biology (2023)
Xianbing Zhu, Zheng Fu, Shary Y Chen, Dionzie Ong, Giulio Aceto, Rebecca Ho, Jutta Steinberger, Anie Monast, Virginie Pilon, Eunice Li, Monica Ta, Kyle Ching, Bianca N Adams, Gian Luca Negri, Luc Choiniere, Lili Fu, Kitty Pavlakis, Patrick Pirrotte, Daina Z Avizonis, Jeffery M Trent, Bernard E Weissman, Ramon I Klein Geltink, Gregg B Morin, Morag Park, David G Huntsman, William D Foulkes, Yemin Wang, Sidong Huang
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss. Nature communications 14 (1) (2023)
Xianbing Zhu, Zheng Fu, Shary Y Chen, Dionzie Ong, Giulio Aceto, Rebecca Ho, Jutta Steinberger, Anie Monast, Virginie Pilon, Eunice Li, Monica Ta, Kyle Ching, Bianca N Adams, Gian Luca Negri, Luc Choiniere, Lili Fu, Kitty Pavlakis, Patrick Pirrotte, Daina Z Avizonis, Jeffery M Trent, Bernard E Weissman, Ramon I Klein Geltink, Gregg B Morin, Morag Park, David G Huntsman, William D Foulkes, Yemin Wang, Sidong Huang
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss. Nature communications 14 (1) (2023)
Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan Nguyen, Brent Wilkinson, Negar Hosseini, Sarah Nguyen, Jean-Paul Urenda, Gavin Knight, Camilo Rojas, Ilse Flores, Alexander Atamian, Roger Moore, Ritin Sharma, Patrick Pirrotte, Randolph S Ashton, Eric J Huang, Gavin Rumbaugh, Marcelo P Coba, Giorgia Quadrato
Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis. Nature neuroscience (2023)
Bin Amber Zhang, Dandan Zhao, Fang Chen, David E Frankhouser, Huafeng Wang, Khyatiben V Pathak, Lei Dong, Anakaren Torres, Krystine Garcia-Mansfield, Yi Zhang, Dinh Hoa Hoang, Min-Hsuan Chen, Shu Tao, Hyejin Cho, Yong Liang, Danilo Perrotti, Sergio Branciamore, Russell C Rockne, Xiwei Wu, Lucy Ghoda, Ling Li, Jie Jin, Jianjun Chen, Jian Hua Yu, Michael A Caligiuri, Ya-Huei Kuo, Mark Boldin, Rui Su, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci
Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis. Nature communications 14 (1) (2023)
Xianbing Zhu, Zheng Fu, Shary Y Chen, Dionzie Ong, Giulio Aceto, Rebecca Ho, Jutta Steinberger, Anie Monast, Virginie Pilon, Eunice Li, Monica Ta, Kyle Ching, Bianca N Adams, Gian Luca Negri, Luc Choiniere, Lili Fu, Kitty Pavlakis, Patrick Pirrotte, Daina Z Avizonis, Jeffery M Trent, Bernard E Weissman, Ramon I Klein Geltink, Gregg B Morin, Morag Park, David G Huntsman, William D Foulkes, Yemin Wang, Sidong Huang
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss. Nature communications 14 (1) (2023)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Rachel M Lucia, Wei-Lin Huang, Khyatiben V Pathak, Marissa McGilvrey, Victoria David-Dirgo, Andrea Alvarez, Deborah Goodman, Irene Masunaka, Andrew O Odegaard, Argyrios Ziogas, Patrick Pirrotte, Trina M Norden-Krichmar, Hannah Lui Park
Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women. Environmental health perspectives 130 (4) (2022)
Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei David Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade. Blood 139 (26) (2022)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Shayesteh R Ferdosi, Brett Taylor, Matthew Lee, Nanyun Tang, Sen Peng, Rita Bybee, George Reid, Lauren Hartman, Krystine Garcia-Mansfield, Ritin Sharma, Patrick Pirrotte, Jianhui Ma, Alison D Parisian, Frank B Furnari, Harshil D Dhruv, Michael E Berens
PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors. Neuro-oncology 24 (11) (2022)
Kristin L Leskoske, Krystine Garcia-Mansfield, Ritin Sharma, Aparna Krishnan, Jessica M Rusert, Jill P Mesirov, Robert J Wechsler-Reya, Patrick Pirrotte
Subgroup-Enriched Pathways and Kinase Signatures in Medulloblastoma Patient-Derived Xenografts. Journal of proteome research 21 (9) (2022)
Havell Markus, Jun Zhao, Tania Contente-Cuomo, Michelle D Stephens, Elizabeth Raupach, Ahuva Odenheimer-Bergman, Sydney Connor, Bradon R McDonald, Bethine Moore, Elizabeth Hutchins, Marissa McGilvrey, Michelina C de la Maza, Kendall Van Keuren-Jensen, Patrick Pirrotte, Ajay Goel, Carlos Becerra, Daniel D Von Hoff, Scott A Celinski, Pooja Hingorani, Muhammed Murtaza
Analysis of recurrently protected genomic regions in cell-free DNA found in urine. Science translational medicine 13 (581) (2021)
Claudia Fredolini, Khyatiben V Pathak, Luisa Paris, Kristina M Chapple, Kristine A Tsantilas, Matthew Rosenow, Tony J Tegeler, Krystine Garcia-Mansfield, Davide Tamburro, Weidong Zhou, Paul Russo, Samuele Massarut, Francesco Facchiano, Claudio Belluco, Ruggero De Maria, Enrico Garaci, Lance Liotta, Emanuel F Petricoin, Patrick Pirrotte
Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection. Breast cancer research : BCR 22 (1) (2020)
Jennifer X Ji, Dawn R Cochrane, Basile Tessier-Cloutier, Shary Yutin Chen, Germain Ho, Khyatiben V Pathak, Isabel N Alcazar, David A Farnell, Samuel Leung, Angela Cheng, Christine Chow, Shane Colborne, Gian Luca Negri, Friedrich Kommoss, Anthony Karnezis, Gregg B Morin, Jessica Nell McAlpine, C Blake Gilks, Bernard E Weissman, Jeffery M Trent, Lynn Hoang, Patrick Pirrotte, Yemin Wang, David G Huntsman
Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase-Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (16) (2020)