T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion.

Laura T Morton Tassilo L A Wachsmann Miranda H MeeuwsenAnne K WoutersDennis F G RemstMarleen M van LoenenJ H Frederik FalkenburgMirjam H M Heemskerk

Published in: Journal for immunotherapy of cancer (2022)

NK-TCR cell therapy enhances NK cell efficacy against tumors through additional TCR-mediated lysis. Furthermore, the dual efficacy of NK-TCR permits the specific targeting of tumors and the associated TCR-associated immune resistance, making NK-TCR a unique cellular therapeutic.

Keyphrases

nk cells
regulatory t cells
cell therapy
dendritic cells
cancer therapy