GPR34 in spinal microglia exacerbates neuropathic pain in mice.

Akira SayoHiroyuki KonishiMasaaki KobayashiKuniyuki KanoHiroki KobayashiHideharu HibiJunken AokiHiroshi Kiyama

Published in: Journal of neuroinflammation (2019)

Inhibition of GPR34-mediated signal by GPR34 gene deletion reduced nerve injury-induced neuropathic pain by suppressing pro-inflammatory responses of microglia without affecting their morphology. Therefore, the suppression of GPR34 activity may have therapeutic potential for alleviating neuropathic pain.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
fatty acid
diabetic rats
type diabetes
adipose tissue
gene expression
copy number
genome wide identification