Human Macrophage Long Intergenic Noncoding RNA, SIMALR , Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1).

Esther CynnDaniel Y LiMarcella E O'ReillyYing WangAlexander C BashoreAnjali JhaAndrea S Foulkes Hanrui Zhang Hanna Winter Lars Maegdefessel Hanying YanMingyao LiLeila RossChenyi XueMuredach P Reilly

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

partners with HIF1α (hypoxia-inducible factor 1 subunit alpha) to regulate NTN1, which is a known macrophage survival factor. This work illustrates the importance of interrogating the functions of human lncRNAs and exploring their translational and therapeutic potential in human atherosclerosis.

Keyphrases

endothelial cells
induced pluripotent stem cells
adipose tissue
oxidative stress
pluripotent stem cells
cardiovascular disease
type diabetes
cell death
endoplasmic reticulum stress
transcription factor
cell cycle arrest
hiv infected
network analysis
nucleic acid