Acute and long-term toxicity in patients undergoing induction chemotherapy followed by thermoradiotherapy for advanced cervical cancer.
X S GaoI A BoereH J van BeekhuizenMartine FranckenaRemi A NoutM J H A KruipM D KulawskaH C van DoornPublished in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2022)
Achieving a five-year overall survival of 58%, platinum-based induction chemotherapy followed by thermoradiotherapy is an effective treatment for advanced-stage high-risk cervical cancer. However, treatment is accompanied by an unacceptably high prevalence of chemotherapy-associated TEE and acute kidney injury, as well as chronic kidney disease. Future studies should investigate the role of carboplatin in reducing toxicity and the effect of thromboprophylaxis in high-risk patients.
Keyphrases
- end stage renal disease
- chronic kidney disease
- acute kidney injury
- patients undergoing
- locally advanced
- peritoneal dialysis
- oxidative stress
- ejection fraction
- newly diagnosed
- liver failure
- randomized controlled trial
- squamous cell carcinoma
- clinical trial
- venous thromboembolism
- prognostic factors
- intensive care unit
- hepatitis b virus
- respiratory failure
- atrial fibrillation
- patient reported