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Magnesium Deficiency Induces Lipid Accumulation in Vascular Endothelial Cells via Oxidative Stress-The Potential Contribution of EDF-1 and PPARγ.

Laura LocatelliGiorgia FedeleSara CastiglioniJeanette A Maier
Published in: International journal of molecular sciences (2021)
Our results suggest that magnesium deficiency leads to the deposition of lipids by inducing EDF-1 and PPARγ. The increase in intracellular lipids might be interpreted as an adaptive response of endothelial cells to magnesium deficiency.
Keyphrases
  • endothelial cells
  • oxidative stress
  • fatty acid
  • replacement therapy
  • high glucose
  • insulin resistance
  • type diabetes
  • ischemia reperfusion injury
  • reactive oxygen species
  • risk assessment
  • heat stress