Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study.
Yan ChengCátia MonteiroAndreia MatosJiaying YouAvelino FragaCarina PereiraVictoria CatalánAmaia RodríguezJavier Gómez-AmbrosiGema FrühbeckRicardo RibeiroPingzhao HuPublished in: Clinical epigenetics (2018)
Results showed that the whole epigenome methylation profiles of PPAT were significantly different in OB/OW compared to normal weight PCa patients. The epigenetic variation associated with excess adiposity likely resulted in altered lipid metabolism and immune dysregulation, contributing towards unfavorable PCa microenvironment, thus warranting further validation studies in larger samples.
Keyphrases
- dna methylation
- prostate cancer
- genome wide
- adipose tissue
- insulin resistance
- gene expression
- end stage renal disease
- newly diagnosed
- weight gain
- chronic kidney disease
- ejection fraction
- stem cells
- radical prostatectomy
- body mass index
- high fat diet
- type diabetes
- physical activity
- copy number
- single cell
- peritoneal dialysis
- fatty acid
- weight loss
- case control