Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
Marlies BodeGeorg R HerrnstadtLeonie DreherNicolas EhnertPia KirkerupMaja T LindenmeyerCatherine Meyer-SchwesingerHeimo EhmkeJörg KöhlTobias B HuberChristian F KrebsOliver M SteinmetzThorsten WiechUlrich O WenzelPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Hypertensive nephropathy in mice and men is characterized by an increase of renal regulatory T cells and enhanced expression of anaphylatoxin receptors. Our investigations do not corroborate a role for C3aR/C5aR1 axis in Ang II-induced hypertension hence challenging the concept of anaphylatoxin receptor targeting in the treatment of hypertensive disease.