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Immunotherapeutic strategies for treating opioid use disorder and overdose.

Rachel LubaSuky MartinezJermaine D JonesMarco PravetoniSandra D Comer
Published in: Expert opinion on investigational drugs (2023)
The present opioid overdose and OUD crises necessitate urgent development and implementation of effective treatments, especially those that offer protection from overdose and can serve as adjuvants to existing medications. Promising preclinical trial results paired with careful efforts to develop vaccines that account for prior SUD vaccine shortcomings offer hope for current and future clinical trials of opioid vaccines. Clinical advantages of opioid vaccines appear to outnumber disadvantages, which may result in improved treatment options.
Keyphrases
  • chronic pain
  • pain management
  • clinical trial
  • phase ii
  • primary care
  • quality improvement
  • phase iii
  • study protocol
  • randomized controlled trial
  • open label
  • bone marrow
  • double blind