Age- and Sex-Dependent Nicotine Pretreatment Effects on the Enhancement of Methamphetamine Self-Administration in Sprague-Dawley Rats.

A majority of polysubstance users begin smoking before the age of 18. Mounting evidence highlights adolescent susceptibility to nicotine exposure on brain and behavior. With the escalation in nicotine-containing products and stimulant use among adolescents, it is important to identify the consequences from adolescent nicotine use, including polysubstance use. Our study provides evidence that adolescent nicotine exposure enhances subsequent methamphetamine use, with important sex- and age-dependent effects.