Genetic Architecture and Clinical Outcomes of Combined Lipid Disturbances.

Thomas C Gilliland Jacqueline S Dron Margaret Sunitha Selvaraj Mark Trinder Kaavya Paruchuri Sarah M Urbut Sara Haidermota Rachel Bernardo M D Mesbah Uddin Michael C Honigberg Gina M Peloso Pradeep Natarajan

Published in: Circulation research (2024)

Simultaneous assessment of multiple lipid derangements revealed nuanced differences in coronary artery disease risk and genetic architectures across dyslipoproteinemia subtypes. These findings highlight the importance of looking beyond single lipid traits to better understand combined lipid and lipoprotein phenotypes and implications for disease risk.

Keyphrases

coronary artery disease
genome wide
fatty acid
heart failure
percutaneous coronary intervention
copy number
type diabetes
gene expression
cardiovascular disease
single cell
cardiovascular events
dna methylation
left ventricular
transcatheter aortic valve replacement
aortic valve
clinical evaluation