Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
Eleanor WheelerAaron LeongChing-Ti LiuMarie-France HivertRona Juliette StrawbridgeClara PodmoreMan LiJie YaoXueling S SimJaeyoung HongAudrey Y ChuWeihua ZhangXu WangPeng ChenNisa M MaruthurBianca C PornealaStephen J SharpYucheng JiaEdmond K KabagambeLi-Ching ChangWei-Min ChenCathy E ElksDaniel S EvansQiao FanFranco GiulianiniMin Jin GoJouke-Jan HottengaYao HuAnne U JacksonStavroula KanoniYoung Jin KimMarcus E KleberClaes LadenvallCecile LecoeurSing-Hui LimYingchang LuAnubha MahajanCarola MarziMike A NallsPau NavarroIlja M NolteLynda M RoseDenis V RybinSerena SannaYuan ShiDaniel O StramFumihiko TakeuchiShu Pei TanPeter J van der MostJana V Van Vliet-OstaptchoukAndrew WongLoic YengoWanting ZhaoAnuj GoelMaria Teresa Martinez LarradDörte RadkePerttu SaloToshiko TanakaErik P A van IperenGoncalo AbecasisSaima AfaqBehrooz Z AlizadehAlain G BertoniAmelie BonnefondYvonne BöttcherErwin P BöttingerHarry CampbellOlga D CarlsonChien-Hsiun ChenYoon Shin ChoW Timothy GarveyChristian GiegerMark O GoodarziHarald GrallertAnders HamstenCatharina A HartmanChristian HerderChao Agnes HsiungJie HuangMichiya IgaseMasato IsonoTomohiro KatsuyaChiea-Chuen KhorWieland KiessKatsuhiko KoharaPeter KovacsJuyoung LeeWen-Jane LeeBenjamin LehneHuaixing LiJianjun LiuStephane LobbensJian'an LuanValeriya LyssenkoThomas MeitingerTetsuro MikiIva MiljkovicSanghoon MoonAntonella MulasGabriele MüllerMartina Müller-NurasyidRamaiah NagarajaMatthias NauckJames S PankowOzren PolasekInga ProkopenkoPaula S RamosLaura Rasmussen-TorvikWolfgang RathmannStephen S RichNeil R RobertsonMichael RodenRonan RousselIgor RudanRobert A ScottWilliam R ScottBengt SennbladDavid S SiscovickKonstantin StrauchLiang SunMorris A SwertzSalman M TajuddinKent D TaylorYik-Ying TeoYih Chung ThamAnke TönjesNicholas J WarehamGonneke WillemsenTom WilsgaardAroon D Hingoraninull nullnull nullnull nullJosephine EganLuigi FerruciG Kees HovinghAntti JulaMika KivimakiMeena KumariInger NjølstadColin Neil Alexander PalmerManuel Serrano RíosMichael StumvollHugh WatkinsTin AungMatthias BlüherMichael BoehnkeDorret I BoomsmaStefan R BornsteinJohn C ChambersDaniel I ChasmanYii-Der Ida ChenYduan-Tsong ChenChing-Yu ChengFrancesco CuccaEco J C N de GeusPanos DeloukasMichele K EvansMyriam FornageYechiel FriedlanderPhilippe FroguelLeif GroopMyron D GrossTamara B HarrisCaroline HaywardChew-Kiat HengErik IngelssonNorihiro KatoBong-Jo KimWoon-Puay KohJaspal S KoonerAntje KörnerDiana KuhJohanna KuusistoMarkku LaaksoXu LinYongmei LiuRuth J F LoosPatrik K E MagnussonWinfried MärzMark I McCarthyAlbertine J OldehinkelKen K OngNancy L PedersenMark A PereiraAnnette PetersPaul M RidkerSabanayagam CharumathiMichele M SaleDanish SaleheenJuha SaltevoPeter Eh SchwarzWayne H H SheuHarold SniederTimothy D SpectorYasuharu TabaraJaakko TuomilehtoRob Martinus van DamJames G WilsonJames F WilsonBruce H R WolffenbuttelTien-Yin WongJer-Yuarn WuWoon-Puay KohAlan B ZondermanNicole SoranzoXiuqing GuoDavid J RobertsJose C FlorezRobert SladekJosée DupuisAndrew P MorrisE-Shyong TaiElizabeth SelvinJerome I RotterClaudia LangenbergInês A BarrosoJames B MeigsPublished in: PLoS medicine (2017)
As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.