Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry.
Marwa AmerAhmed M KamelMohammed BawazeerKhalid MaghrabiAbid ButtTalal DahhanEiad KseibiSyed Moazzum KhurshidMohammed AbujazarRazan AlghunaimMuath RabeeMaal AbualkhairAli Al-JanoubiAbeer Turki AlFirmOgnjen GajicAllan J WalkeyJarrod M MosierIgor Borisovich ZabolotskikhOscar Y GavidiaSantiago Yus- TeruelMichael A BernsteinKaren BomanVishakha K KumarVikas BansalRahul Kashyapnull nullPublished in: European journal of medical research (2021)
Discordance was observed between the registry utilization patterns (i.e., timing of steroids and IL-6RA administration) and new evidence from the recent randomized controlled trials and guideline recommendations. These data will help us to identify areas of improvement in prescribing patterns and enhance our understanding of IL-6RA safety with different steroid regimens. Further studies are needed to evaluate the drivers of hospital-level variation and their impact on clinical outcomes. Trial registration ClinicalTrials.gov: NCT04486521. Registered on July 2020.
Keyphrases
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- primary care
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- ankylosing spondylitis
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