Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages.
Pamelia N LimMaritza Montserrat CervantesLinh K PhamSydney DohertyAnkita TuftsDivya DubeyDat MaiAlan AderemAlan H DiercksAlissa C RothchildPublished in: bioRxiv : the preprint server for biology (2024)
Alveolar macrophages (AMs) do not produce TNF or IL-6 in response to low-dose LPS due to minimal surface expression of TLR4 and CD14Lack of AM IL-10 production is dependent on low c-Maf expressionExogenous c-Maf expression increases AM IL-10 productionIFNβ enhances AM TNF and IL-6 responses to low-dose LPS and this is dependent on a lack of IL-10.