Mechanistic Modeling of Intrathecal Chemotherapy Pharmacokinetics in the Human Central Nervous System.
Jing LiAndrew WuSeongho KimPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
CNS PBPK modeling, in line with available clinical efficacy data, confirms the therapeutic value of intrathecal chemotherapy with antibody or small-molecule drugs for treating neoplastic meningitis and warrants further clinical investigation of intrathecal antibody drugs to treat brain parenchyma tumors. Compared with intraventricular injection, intraventricular 24-hour infusion may mitigate neurotoxicity while retaining potential efficacy.
Keyphrases
- small molecule
- locally advanced
- endothelial cells
- cerebrospinal fluid
- blood pressure
- white matter
- resting state
- electronic health record
- blood brain barrier
- induced pluripotent stem cells
- big data
- protein protein
- squamous cell carcinoma
- pluripotent stem cells
- radiation therapy
- rectal cancer
- drug induced
- chemotherapy induced
- functional connectivity
- cerebral ischemia
- multiple sclerosis