Angiotensin-converting enzyme inhibitors provide a protective effect on hypoxia-induced injury in human coronary artery endothelial cells via Nrf2 signaling and PLVAP.
Qiubing ZhangFang GouPing ShiZhe XuZhitao YanMingfang HeXiaohong YinYuanjun HeJun ZhangPublished in: Clinical hemorheology and microcirculation (2024)
ACEI protects hypoxia-treated HEAECs by activating the Nrf2 signaling pathway and upregulating the expression of PLVAP.
Keyphrases
- endothelial cells
- angiotensin converting enzyme
- signaling pathway
- coronary artery
- angiotensin ii
- oxidative stress
- high glucose
- poor prognosis
- pulmonary artery
- vascular endothelial growth factor
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- binding protein
- cell proliferation
- induced pluripotent stem cells
- long non coding rna
- pulmonary hypertension
- endoplasmic reticulum stress