Hemostatic Biomarkers and Venous Thromboembolism Are Associated With Mortality and Response to Chemotherapy in Patients With Pancreatic Cancer.

Florian MoikGerald PragerJohannes ThalerFlorian PoschSarah WiedemannTheresa SchrammCornelia EnglischNigel MackmanIngrid PabingerCihan Ay

Published in: Arteriosclerosis, thrombosis, and vascular biology (2021)

VTE diagnosis is associated with shorter OS and PFS. Higher baseline levels of D-dimer, extracellular vesicle-tissue factor activity, PAI-1, and sP-selectin were independently prognostic for increased mortality, and D-dimer predicted response to palliative chemotherapy.

Keyphrases

venous thromboembolism
cardiovascular events
direct oral anticoagulants
locally advanced
risk factors
palliative care
cardiovascular disease
squamous cell carcinoma
advanced cancer
rectal cancer