The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats.

Bilal Sahin Ercan Ozdemir Erkan Gumus Mustafa Ergul Ahmet Şevki Taşkıran

Published in: Neurological research (2022)

5-HT7 antagonist SB-269970 displays anticonvulsant effects on PTZ-induced seizures in fully kindled rats and these effects may be related to GABAergic activity in the hippocampus.

Keyphrases

high glucose
diabetic rats
poor prognosis
oxidative stress
endothelial cells
cerebral ischemia
cognitive impairment
binding protein