RNA-Seq Analysis of Genetic and Transcriptome Network Effects of Dual-Trait Selection for Ethanol Preference and Withdrawal Using SOT and NOT Genetic Models.

Laura B Kozell Denesa L OberbeckPriscila DarakjianStephanie EdmundsKaren ShepherdsonKari J BuckRobert Hitzemann

Published in: Alcoholism, clinical and experimental research (2020)

Marked effects of selection on gene expression were detected. The NOT line was characterized by higher expression of hub nodes associated with mitochondrial function. Genes more highly expressed in the SOT aligned with previous findings, for example, Colville and colleagues (Genes Brain Behav 16, 2017, 462) that both high EtOH preference and consumption are associated with effects on cell adhesion and glutamate synaptic plasticity.

Keyphrases

genome wide
rna seq
dna methylation
cell adhesion
gene expression
single cell
copy number
bioinformatics analysis
poor prognosis
white matter
network analysis
resting state
squamous cell carcinoma
multiple sclerosis
genome wide identification
sentinel lymph node
subarachnoid hemorrhage
cerebral ischemia