RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.

Mengnuo ChenLai WeiCheuk-Ting LawFelice Ho-Ching TsangJialing ShenCarol Lai-Hung ChengLong-Hin TsangDaniel Wai-Hung HoDavid Kung-Chun ChiuJoyce Man-Fong LeeCarmen Chak-Lui WongIrene Oi-Lin NgChun Ming Wong

Published in: Hepatology (Baltimore, Md.) (2018)

METTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270).

Keyphrases

endothelial cells
poor prognosis
dna methylation
gene expression
transcription factor
induced pluripotent stem cells
binding protein
long non coding rna