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4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.

Ting LiJia-Wen LiYing-Hui QinRiu LiuXiao-Na XuXiao LiLi-Min LiBin FengLi YangChun-Sheng Yang
Published in: Annals of clinical and translational neurology (2024)
4-OI could effectively inhibit NLRP3 signaling, leading to the inhibition of proinflammatory cytokine production in patients with NMOSD-derived PBMCs and in a human macrophage model. Thus, 4-OI and itaconate could have important therapeutic value for the treatment of NMOSD in the future.
Keyphrases
  • endothelial cells
  • oxidative stress
  • nlrp inflammasome
  • adipose tissue
  • induced pluripotent stem cells
  • current status
  • pluripotent stem cells
  • spectrum disorder