How to treat patients with rheumatoid arthritis when methotrexate has failed? The use of a multiple propensity score to adjust for confounding by indication in observational studies.

Sytske Anne BergstraLai-Ling WinchowElizabeth MurphyArvind ChopraKaren Salomon-EscotoJoão Eurico FonsecaCornelia F AllaartRobert B M Landewé

Published in: Annals of the rheumatic diseases (2018)

In this analysis of worldwide common practice data with adjustment for multiple PS, patients with RA who had failed initial treatment with methotrexate monotherapy had a better DAS-response after a subsequent switch to a bDMARD-containing treatment regimen than to a regimen with csDMARD(s) only, with or without glucocorticoids.

Keyphrases

combination therapy
high dose
primary care
rheumatoid arthritis
randomized controlled trial
big data
systemic sclerosis
smoking cessation