Aberrant expression of CD10 and BCL6 in mantle cell lymphoma.
Marco PizziClaudio AgostinelliSimona RighiAnna GazzolaClaudia MannuFrancesca GaluppiniAngelo Paolo Dei TosAndrea VisentinFrancesco PiazzaGianpietro C SemenzatoMassimo RuggeSabattini ElenaPublished in: Histopathology (2017)
Aberrant CD10 and BCL6 expression defines a subset of MCLs with higher mean Ki-67 index and higher prevalence of MUM1 expression. BCL6 protein positivity correlates with cytogenetic aberrations involving the BCL6 gene. Although examined successfully in few cases, the high prevalence of unmutated IGVH genes also points at a pregerminal cell origin for these phenotypically aberrant cases.