Genome-Protective Topoisomerase 2a-Dependent G2 Arrest Requires p53 in hTERT-Positive Cancer Cells.

Nicola LockwoodSilvia MartiniAinara Lopez-PardoKatharina DeissHendrika A SegerenRobert K SempleIan CollinsDimitra RepanaMathias Cobbaut Tanya N SolimanFrancesca CiccarelliPeter J Parker

Published in: Cancer research (2022)

The identification of a requirement for p53 in stringent Topo2a-dependent G2 arrest and engagement of PKCε failsafe pathways in arrest-defective hTERT-positive cells provides a therapeutic opportunity to induce selective synthetic lethality.

Keyphrases

cell cycle
induced apoptosis
cell cycle arrest
social media
cell proliferation
genome wide
endoplasmic reticulum stress
oxidative stress
gene expression
signaling pathway