Temperature-Controlled Mechanochemistry Unlocks the Nickel-Catalyzed Suzuki-Miyaura-Type Coupling of Aryl Sulfamates at Different Scales.

Several mechanochemically heated processes have been published in recent years. However, precise control over the mechanochemical catalysed coupling reactions remained elusive. A recent report from Leitch, Browne and co-workers demonstrated how a programmable jar heater manifold delivers an efficient methodology for the Suzuki-Miyaura-type cross coupling reaction of aryl sulfamates and aryl boronic acid species. This methodology can be readily upscaled 200-fold using twin-screw extrusion methodologies.