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Associations between cuprotosis-related genes and the spectrum of metabolic dysfunction-associated fatty liver disease: An exploratory study.

Hai-Yang YuanWen-Yue LiuGong FengSui-Dan ChenXin-Zhe JinLi-Li ChenZi-Jun SongKe LiChristopher D ByrneGiovanni TargherNa TianGang LiXin-Lei ZhangJacob GeorgeMeng ZhouFudi WangMing-Hua Zheng
Published in: Diabetes, obesity & metabolism (2024)
GLS may contribute to liver inflammation and fibrosis in MAFLD mainly through cuprotosis and T-cell activation, promoting the progression of MAFLD to HCC. These findings suggest that cuprotosis may play a role in MAFLD progression, potentially providing new insights into MAFLD pathogenesis.
Keyphrases
  • oxidative stress
  • fatty acid