Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer.

Tian ZhangJulie KephartElizabeth BronsonMonika AnandChristine DalyIvan SpasojevicSubha BakthavatsalamKatherine FranzHannah BergGeorgia S KarachaliouOlga G JamesLauren HowardSusan HalabiMichael R HarrisonAndrew J ArmstrongDaniel J George

Published in: The Prostate (2022)

Oral DSF is not an effective treatment for mCRPC due to rapid metabolism into an inactive metabolite, Me-DDC. This trial has stopped enrollment and further work is needed to identify a stable DSF formulation for treatment of mCRPC.

Keyphrases

clinical trial
squamous cell carcinoma
small cell lung cancer
study protocol
randomized controlled trial
open label
health insurance
replacement therapy