Effects of PB-TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblasts.

Jasmine A FelsJalia DashKent LeslieGiovanni ManfrediHibiki Kawamata

Published in: Annals of clinical and translational neurology (2022)

This study is the first to explore the molecular effects of Combo in ALS patient-derived cells. It shows that Combo has a greater and distinct impact compared with the individual compounds and provides clues to drug targets and mechanisms of action, which may underlie the benefits of this investigational drug combination.

Keyphrases

amyotrophic lateral sclerosis
induced apoptosis
cell cycle arrest
gene expression
heavy metals
transcription factor
adverse drug
randomized controlled trial
emergency department
drug induced
late onset
cell death
extracellular matrix
oxidative stress
early onset