Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study.
Yun LiuMelissa N EliotGeorge D PapandonatosKarl T KelseyRuby ForeScott M LangevinJessie P BuckleyAimin ChenBruce P LanphearKim M CecilKimberly YoltonMarie-France HivertSharon K SagivAndrea A BaccarelliEmily OkenJoseph M BraunPublished in: Environmental health perspectives (2022)
In these longitudinal data, PFAS biomarkers were associated with differences in several CpGs at birth and at 12 years of age in or near genes linked to some PFAS-associated health outcomes. Future studies should examine whether DNA methylation mediates associations between gestational PFAS exposure and health. https://doi.org/10.1289/EHP10118.
Keyphrases
- dna methylation
- genome wide
- weight gain
- pregnancy outcomes
- gene expression
- pregnant women
- gestational age
- birth weight
- healthcare
- public health
- copy number
- body mass index
- electronic health record
- cross sectional
- health information
- big data
- machine learning
- physical activity
- deep learning
- risk assessment
- preterm birth
- climate change
- artificial intelligence
- weight loss
- bioinformatics analysis